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Tell your provider if you have a current or past history of: Diabetic retinopathy Pancreas or kidney problems, such as a history of pancreatitis Medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 Severe gastrointestinal disease like gastroparesis (delayed gastric emptying that causes nausea, vomiting, bloating) Serious allergy to tirzepatide, including anaphylaxis Dietary and lifestyle adjustments with tirzepatide Tirzepatide is designed to be used with a reduced-calorie diet and regular exercise, which will help you get the most significant benefits for both weight loss and blood sugar control